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Anterior mitral leaflet curvature in the beating ovine heart: a case study using videofluoroscopic markers and subdivision surfaces
Date
2010-06-01
Author
Göktepe, Serdar
Kvitting, JPE
Swanson, Julia
Ingels, Neil
Miller, Craig
Kuhl, Ellen
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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
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The implantation of annuloplasty rings is a common surgical treatment targeted to re-establish mitral valve competence in patients with mitral regurgitation. It is hypothesized that annuloplasty ring implantation influences leaflet curvature, which in turn may considerably impair repair durability. This research is driven by the vision to design repair devices that optimize leaflet curvature to reduce valvular stress. In pursuit of this goal, the objective of this manuscript is to quantify leaflet curvature in ovine models with and without annuloplasty ring using in vivo animal data from videofluoroscopic marker analysis. We represent the surface of the anterior mitral leaflet based on 23 radiopaque markers using subdivision surfaces techniques. Quartic box-spline functions are applied to determine leaflet curvature on overlapping subdivision patches. We illustrate the virtual reconstruction of the leaflet surface for both interpolating and approximating algorithms. Different scalar-valued metrics are introduced to quantify leaflet curvature in the beating heart using the approximating subdivision scheme. To explore the impact of annuloplasty ring implantation, we analyze ring-induced curvature changes at characteristic instances throughout the cardiac cycle. The presented results demonstrate that the fully automated subdivision surface procedure can successfully reconstruct a smooth representation of the anterior mitral valve from a limited number of markers at a high temporal resolution of approximately 60 frames per minute.
Subject Keywords
Biotechnology
,
Mechanical Engineering
,
Modelling and Simulation
URI
https://hdl.handle.net/11511/48389
Journal
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
DOI
https://doi.org/10.1007/s10237-009-0176-z
Collections
Department of Civil Engineering, Article
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Anterior Mitral Leaflet Curvature During the Cardiac Cycle in the Normal Ovine Heart
Kvitting, JPE; Bothe, Wolfgang; Göktepe, Serdar; Rausch, Manuel; Swanson, Julia; Kuhl, Ellen; Ingels, Neil; Miller, Craig (Ovid Technologies (Wolters Kluwer Health), 2010-10-26)
Background-The dynamic changes of anterior mitral leaflet (AML) curvature are of primary importance for optimal left ventricular filling and emptying but are incompletely characterized.
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S. Göktepe, J. Kvitting, J. Swanson, N. Ingels, C. Miller, and E. Kuhl, “Anterior mitral leaflet curvature in the beating ovine heart: a case study using videofluoroscopic markers and subdivision surfaces,”
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
, pp. 281–293, 2010, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/48389.