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Biomaterials and Tissue Engineering Application and Research Center (BİOMATEN)

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Behavior of mammalian cells on magnesium substituted bare and hydroxyapatite deposited (Ti, Mg) N coatings
Önder, Sakip; Calikoglu-Koyuncu, Ayşe Ceren; Kazmanli, Kürşat; Ürgen, Mustafa; Köse, Gamze Torun; Kök, Fatma Neşe (Elsevier BV, 2015-12-25)
TiN and (Ti,Mg)N thin film coatings were deposited on titanium substrates by using cathodic arc physical vapor deposition (arc-PVD) technique with magnesium contents of 0, 4.24 at% (low Mg) and 10.42 at% (high Mg). The pre...
Optimisation of micro-arc oxidation electrolyte for fabrication of antibacterial coating on titanium
Aydogan, Dilek Teker; Muhaffel, Faiz; Kilic, Meryem Menekse; Acar, Ozge Karabiyik; Cempura, Grzegorz; Baydoğan, Murat; Gül-karagüler, Nevin; Kose, Gamze Torun; Czyrska-Filemonowicz, Aleksandra; Çimenoğlu, Hüseyin (2018-01-01)
This study has been carried out to optimise the silver (Ag) content of the coating synthesised on commercially pure titanium (Cp-Ti, Grade 4) for biomedical applications by micro-arc oxidation (MAO) process. The MAO proces...
Chondrogenic potential of macroporous biodegradable cryogels based on synthetic poly(alpha-amino acids)
Sedlacik, T.; Acar, O. K.; Studenovska, H.; Kotelnikov, I.; Kucka, J.; Konecna, Z.; Zikmund, T.; Kaiser, J.; KÖSE, GAMZE; Rypacek, F. (Royal Society of Chemistry (RSC), 2018-01-14)
In this study, the potential of highly porous hydrogels based on biodegradable synthetic poly(alpha-amino acids) to support proliferation and chondrogenesis of human dental pulp stem cells (hDPSCs) was investigated. Covale...
Surface modification of Ti6Al4V by micro-arc oxidation in AgC2H3O2-containing electrolyte
Aydogan, Dilek Teker; Muhaffel, Faiz; Acar, Ozge Karabiyik; Topcuoglu, Emine Nursen; Kulekci, Hatice Guven; Kose, Gamze Torun; Baydoğan, Murat; Çimenoğlu, Hüseyin (2018-09-01)
This study focuses on the biological properties of Ti6Al4V after employing micro-arc oxidation in sodium phosphateand calcium acetate-containing electrolyte with and without addition of silver acetate. After micro-arc oxid...
Bone response to biomimetic implants delivering BMP-2 and VEGF: An immunohistochemical study
RAMAZANOĞLU, Mustafa; Lutz, Rainer; Rusche, Philipp; Trabzon, Levent; Kose, Gamze Torun; Prechtl, Christopher; Schlegel, Karl Andreas (2013-12-01)
This animal study evaluated bone healing around titanium implant surfaces biomimetically coated with bone morphogenic protein-2 (BMP-2) and/or vascular endothelial growth factor (VEGF) by examining bone matrix proteins and...
Collagen and polyester-based scaffolds for tissue engineering
Hasyrcy, V.; Kenar, H.; Yucel, D.; Zorlutuna, P.; Yylgor, P.; KÖSE, GAMZE; Hasyrcy, N. (2009-03-22)
Poly( amino acid)-based fibrous scaffolds modified with surface-pendant peptides for cartilage tissue engineering
Svobodova, Jana; Proks, Vladimir; Karabiyik, Ozge; Koyuncu, Ayse Ceren Calikoglu; Kose, Gamze Torun; Rypacek, Frantisek; Studenovska, Hana (Wiley, 2017-03-01)
In this study, fibrous scaffolds based on poly(gamma-benzyl-L-glutamate) (PBLG) were investigated in terms of the chondrogenic differentiation potential of human tooth germ stem cells (HTGSCs). Through the solution-assiste...
Effect of Magnesium and Osteoblast Cell Presence on Hydroxyapatite Formation on (Ti,Mg)N Thin Film Coatings
Onder, Sakip; Calikoglu-Koyuncu, Ayse Ceren; Kose, Gamze Torun; Kazmanli, Kursat; Kök, Fatma Neşe; Urgen, Mustafa (Springer Science and Business Media LLC, 2017-07-01)
TiN and (Ti,Mg)N thin film coatings were deposited on Ti substrates by an arc-physical vapor deposition technique. The effect of cell presence on hydroxyapatite (HA) formation was investigated using surfaces with four diff...
Magnesium doping on TiN coatings affects mesenchymal stem cell differentiation and proliferation positively in a dose-dependent manner
ÖNDER, Sakip; Calikoglu-Koyuncu, Ayse Ceren; Kazmanli, Kursat; Urgen, Mustafa; Kök, Fatma Neşe; KÖSE, GAMZE (IOS Press, 2018-01-01)
BACKGROUND: In vitro evaluation of cell-surface interactions for hard tissue implants have mostly been done using osteoblasts. However, when an implant is placed in the body, mesenchymal stem cells (MSCs) play a major role...
Influence of STRO-1 selection on osteogenic potential of human tooth germ derived mesenchymal stem cells
Ercal, Pinar; Pekozer, Gorke G.; Gumru, Osman Z.; KÖSE, GAMZE; Ramazanoglu, Mustafa (Elsevier BV, 2017-10-01)
Mesenchymal stem cells derived from the human tooth germ (hTGSCs) are a heterogeneous cell population that can differentiate into osteogenic, neurogenic, and adipogenic lineages. The aim of this study was to compare the os...