Biomaterials and Tissue Engineering Application and Research Center (BİOMATEN)

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Ermiş Şen, Menekşe (7)
Hasırcı, Vasıf Nejat (7)
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Recent Submissions

Effects of amyloid-β-mimicking peptide hydrogel matrix on neuronal progenitor cell phenotype Mathes, Tess Grett; Monirizad, Mahsa; Ermiş Şen, Menekşe; de Barros, Natan Roberto; Rodriguez, Marco; Kraatz, Heinz-Bernhard; Jucaud, Vadim; Khademhosseini, Ali; Falcone, Natashya (2024-07-15) Self-assembling peptide-based hydrogels have become a highly attractive scaffold for three-dimensional (3D) in vitro disease modeling as they provide a way to create tunable matrices that can resemble the extracellular mat...
Recent Developments in Glioblastoma-On-A-Chip for Advanced Drug Screening Applications Maity, Surjendu; et. al. (2024-01-01) Glioblastoma (GBM) is an aggressive form of cancer, comprising ≈80% of malignant brain tumors. However, there are no effective treatments for GBM due to its heterogeneity and the presence of the blood-brain barrier (BBB), ...
Gelatin methacryloyl and Laponite bioink for 3D bioprinted organotypic tumor modeling de Barros, Natan Roberto; et. al. (2023-07-20) Three-dimensional (3D)in vitrotumor models that can capture the pathophysiology of human tumors are essential for cancer biology and drug development. However, simulating the tumor microenvironment is still challenging bec...
A Cell Culture Chip with Transparent, Micropillar-Decorated Bottom for Live Cell Imaging and Screening of Breast Cancer Cells Ermiş Şen, Menekşe; ANTMEN ALTUNSOY, EZGİ; Kuren, Ozgur; Demirci, Utkan; Hasırcı, Vasıf Nejat (2022-01-01) In the recent years, microfabrication technologies have been widely used in cell biology, tissue engineering, and regenerative medicine studies. Today, the implementation of microfabricated devices in cancer research is fr...
Extracellular matrix, cell adhesion, cell substrate interactions, mechanobiology Antmen Altunsoy, Ezgi (Wiley-VCH Verlag Weinheim GmbH, 2021-03-01)
In situ silver nanoparticle synthesis on 3D-printed polylactic acid scaffolds for biomedical applications ÇALAMAK, SEMİH; Ermiş Şen, Menekşe (2021-02-01) An ultraviolet (UV) irradiation-based in situ silver nanoparticle (AgNP) synthesis approach has drawn significant attention for functionalizing a great variety of biomaterials. Here, we designed an AgNP-functionalized 3D-p...
Photo-crosslinked gelatin methacrylate hydrogels with mesenchymal stem cell and endothelial cell spheroids as soft tissue substitutes Ermiş Şen, Menekşe (2021-02-01) Tumors, trauma, and congenital defects require volume restoration of soft tissues. Tissue engineering provides an alternative source for substituting these defects. Cell encapsulation into hydrogels provides a three-dimens...
Micropatterned Surfaces Expose the Coupling between Actin Cytoskeleton-Lamin/Nesprin and Nuclear Deformability of Breast Cancer Cells with Different Malignancies. Antmen Altunsoy, Ezgi; Hasirci, Vasif (2021-01-01) Mechanotransduction proteins transfer mechanical stimuli through nucleo‐cytoskeletal coupling and affect the nuclear morphology of cancer cells. However, the contribution of actin filament integrity has never been studied ...
The effect of high-temperature on foamed concrete CANBAZ, MEHMET; Dakman, Hafid; Arslan, Baris; Büyüksungur, Arda (2019-07-01) Within the scope of this study, the foam solution was prepared by properly mixing sulfonate based foam agent with water. Furthermore, this solution was mixed with the mixture of fine sand, cement, and water to produce foam...
In vitro koşullarda 3 boyutlu kemik tümör modeli geliştirilmesi Hasırcı, Nesrin; Hasırcı, Vasıf Nejat; Antmen, Ezgi (2018-12-15)
Surface modification of Ti6Al4V by micro-arc oxidation in AgC2H3O2-containing electrolyte Aydogan, Dilek Teker; Muhaffel, Faiz; Acar, Ozge Karabiyik; Topcuoglu, Emine Nursen; Kulekci, Hatice Guven; Kose, Gamze Torun; Baydoğan, Murat; Çimenoğlu, Hüseyin (2018-09-01) This study focuses on the biological properties of Ti6Al4V after employing micro-arc oxidation in sodium phosphateand calcium acetate-containing electrolyte with and without addition of silver acetate. After micro-arc oxid...
Evaluation of Threshold Values for Root Canal Filling Voids in Micro-CT and Nano-CT Images Orhan, Kaan; Jacobs, Reinhilde; Celikten, Berkan; Huang, Yan; de Faria Vasconcelos, Karla; Nicolielo, Laura Ferreira Pinheiro; Buyuksungur, Arda; Van Dessel, Jeroen (Hindawi Limited, 2018-7-16) While several materials and techniques have been used to assess the quality of root canal fillings in micro-CT images, the lack of standardization in scanning protocols has produced conflicting results. Hence, the aim of t...
Chondrogenic potential of macroporous biodegradable cryogels based on synthetic poly(alpha-amino acids) Sedlacik, T.; Acar, O. K.; Studenovska, H.; Kotelnikov, I.; Kucka, J.; Konecna, Z.; Zikmund, T.; Kaiser, J.; KÖSE, GAMZE; Rypacek, F. (Royal Society of Chemistry (RSC), 2018-01-14) In this study, the potential of highly porous hydrogels based on biodegradable synthetic poly(alpha-amino acids) to support proliferation and chondrogenesis of human dental pulp stem cells (hDPSCs) was investigated. Covale...
Magnesium doping on TiN coatings affects mesenchymal stem cell differentiation and proliferation positively in a dose-dependent manner ÖNDER, Sakip; Calikoglu-Koyuncu, Ayse Ceren; Kazmanli, Kursat; Urgen, Mustafa; Kök, Fatma Neşe; KÖSE, GAMZE (IOS Press, 2018-01-01) BACKGROUND: In vitro evaluation of cell-surface interactions for hard tissue implants have mostly been done using osteoblasts. However, when an implant is placed in the body, mesenchymal stem cells (MSCs) play a major role...
Optimisation of micro-arc oxidation electrolyte for fabrication of antibacterial coating on titanium Aydogan, Dilek Teker; Muhaffel, Faiz; Kilic, Meryem Menekse; Acar, Ozge Karabiyik; Cempura, Grzegorz; Baydoğan, Murat; Gül-karagüler, Nevin; Kose, Gamze Torun; Czyrska-Filemonowicz, Aleksandra; Çimenoğlu, Hüseyin (2018-01-01) This study has been carried out to optimise the silver (Ag) content of the coating synthesised on commercially pure titanium (Cp-Ti, Grade 4) for biomedical applications by micro-arc oxidation (MAO) process. The MAO proces...
Gene Therapy Strategies in Bone Tissue Engineering and Current Clinical Applications Atasoy-Zeybek, Aysegul; KÖSE, GAMZE (2018-01-01) Gene therapy provides a promising approach for regeneration and repair of injured bone. Application of gene therapy has displayed increased efficiency in various animal models and preclinical trials in comparison with trad...
Hydrogels as a New Platform to Recapitulate the Tumor Microenvironment Ermiş Şen, Menekşe; Çalıbaşı, Gizem; Güven, Sinan; Durmuş, Naşide Gözde; Rizvi, Imran; Hasan, Tayyaba; Hasırcı, Nesrin; Hasırcı, Vasıf Nejat (2018-01-01) Recent advances in tissue engineering include the incorporation of multiple cell types into three-dimensional (3D) hydrogels to recapitulate extracellular matrix (ECM) structures and the functionality of living tissues in ...
Influence of STRO-1 selection on osteogenic potential of human tooth germ derived mesenchymal stem cells Ercal, Pinar; Pekozer, Gorke G.; Gumru, Osman Z.; KÖSE, GAMZE; Ramazanoglu, Mustafa (Elsevier BV, 2017-10-01) Mesenchymal stem cells derived from the human tooth germ (hTGSCs) are a heterogeneous cell population that can differentiate into osteogenic, neurogenic, and adipogenic lineages. The aim of this study was to compare the os...
Effect of Magnesium and Osteoblast Cell Presence on Hydroxyapatite Formation on (Ti,Mg)N Thin Film Coatings Onder, Sakip; Calikoglu-Koyuncu, Ayse Ceren; Kose, Gamze Torun; Kazmanli, Kursat; Kök, Fatma Neşe; Urgen, Mustafa (Springer Science and Business Media LLC, 2017-07-01) TiN and (Ti,Mg)N thin film coatings were deposited on Ti substrates by an arc-physical vapor deposition technique. The effect of cell presence on hydroxyapatite (HA) formation was investigated using surfaces with four diff...
Skeletal muscle patch engineering on synthetic and acellular human skeletal muscle originated scaffolds Ay, Birol; KARAÖZ, Erdal; KESEMENLİ, CUMHUR CEVDET; KENAR, HALİME (2017-03-01) The reconstruction of skeletal muscle tissue is currently performed by transplanting a muscle tissue graft from local or distant sites of the patient's body, but this practice leads to donor site morbidity in case of large...

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