Test and Measurement Center In advanced Technologies (MERKEZ LABORATUVARI)

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Recent Submissions

Unveiling the effect of Hf-(Mo,W) addition on the coarsening, agglomeration, and dissolution behaviour of γ'-Ni3Al precipitates in model Ni-based superalloys Eriş, Rasim; Akdeniz, Mahmut Vedat; Mehrabov, Amdulla (2023-03-05) In compositional design of Ni-based superalloys, atomic size of alloying elements appears as the primary factor affecting alloy strengthening. Depending on atomic size, the phase partitioning preferences of alloying elemen...
Coffee-Derived Exosome-Like Nanoparticles: Are They the Secret Heroes? Kantarcıoğlu, Murat; Yıldırım, Gülşen; Akpınar Oktar, Pınar; Yanbakan, Serpil; Özer, Zeynep Büşra; Yurtsever Sarıca, Deniz; Taşdelen, Serpil; Bayrak, Emel; Akın Balı, Dilara Fatma; Öztürk, Seçkin; Akçalı, Kamil Can; Ezer, Üstün; Kürekçi, Ahmet Emin (2023-02-01) BACKGROUND: Regular coffee consumption has beneficial and preventative effects on liver and chronic neurodegenerative diseases. However, the studies performed with the ingredients found in coffee beverages have not clarifi...
Facile Synthesis and Origin of Enhanced Electrochemical Oxygen Evolution Reaction Performance of 2H-Hexagonal Ba2CoMnO6-delta as a New Member in Double Perovskite Oxides Erdil, Tuncay; Lökçü, Ersu; Yıldız, İlker; Okuyucu, Can; Kalay, Yunus Eren; Toparlı, Çiğdem (2022-12-06) Perovskite oxides have been considered promising oxygen evolution reaction (OER) electrocatalysts due to their high intrinsic activity. Yet, their poor long-term electrochemical and structural stability is still controvers...
Synthesis and investigation of anti-cancer activity of novel substituted alkylsulfonyl 1H- benzo[d]imidazole derivatives in MCF-7 breast cancer cells Abbade, Yemna; Kışla, Mehmet Murat; Al-Kassim Hassan, Mohammed; Doğan, Tuğba; Mutlu, Pelin; Alagöz, Zeynep (2022-11-24)
Optical 4D oxygen mapping of microperfused tissue models with tunable in vivo-like 3D oxygen microenvironments Wesseler, Milan Finn; Johansen, Mathias Norbaek; Kızıltay, Aysel; Mortensen, Kim; Larsen, Niels B. (2022-10-01) Sufficient and controllable oxygen supply is essential for in vitro 3D cell and tissue culture at high cell densities, which calls for volumetric in situ oxygen analysis methods to quantitatively assess the oxygen distribu...
Late Cretaceous volcanic arc magmatism in southeast Anatolian Orogenic Belt: Constraints from whole-rock, mineral chemistry, Sr-Nd isotopes and U-Pb zircon ages of the Baskil Intrusive Complex (Malatya, Turkey) NURLU, NUSRET; Köksal, Serhat; Kohut, Milan (2022-08-01) The voluminous intrusive and extrusive magmatism was formed in the Elazig-Malatya region of the Southeast Anatolian Orogenic Belt (SAOB) as a consequence of the continental collision and/or convergent orogeny. The SAOB hol...
Combined U-Pb ages and Lu-Hf systematics of detrital zircons from Early Cambrian Gondwanan siliciclastic rocks in S Turkey: Provenance and correlations with coeval successions in peri-Gondwanan terranes Gürsu, Semih; Köksal, Serhat; Möller, Andreas; Kamenov, George D.; Cemal Göncüoğlu, M.; Hefferan, Kevin; Mueller, Paul A.; Kozlu, Hüseyin (2022-07-01) © 2022 International Association for Gondwana ResearchDetrital U-Pb age peaks and εHf(t) and TDM(Hf) of peri-Gondwanan units of S Turkey indicate that they may have been derived from Neoproterozoic igneous suites in the Si...
Lithocholic acid conjugated mPEG-b-PCL micelles for pH responsive delivery to breast cancer cells Isik, Gulhan; Kızıltay, Aysel; Hasırcı, Nesrin; Tezcaner, Ayşen (2022-06-10) © 2022 Elsevier B.V.In this study, micelles composed of methoxy poly(ethylene glycol)-block-poly(ε-caprolactone) copolymer (mPEG-b-PCL), which has ionically conjugated lithocholic acid (LCA) and providing pH sensitive rele...
On the Optimization of the Microstructural and Mechanical Properties of Model Ni-Based Superalloys Through the Alloying Effects of Refractory Mo and W Elements Eriş, Rasim; Akdeniz, Mahmut Vedat; Mehrabov, Amdulla (2022-05-01) In the design and development of next-generation Ni-based superalloys, the addition of refractory impurity elements not only induces better degree of bonding strengthening, but also helps in maintaining structural stabilit...
Preclinical toxicity test results of a new antiviral–immune-modulator compound consisting of flavonoid molecules (COVID-19 clinical trial preliminary data) Budak, Gürer; ÖZKAN, SEÇİL; BUDAK, Mehmet; Şeker, Tamay; MERYEMOĞLU, BAHAR; Miran, Şükran Selin; Çoban, Canan Çakır; Tarkun, Örkun (2022-01-01) Aim: Isolated specific glycone–aglycone conjugated flavonoids which are investigated for their effect of bioavailability and molecular concentrations. The specific formula is then tested via in vitro and in vivo cytotoxici...
Beam dynamic studies at accelerator system of gun for a self-amplified spontaneous emission free electron laser project Yildiz, H. Duran; Porsuk, D.; Yıldız, İlker; Cakir, R. (2022-01-01) One of the important factors in high radiation generation facilities is the production of a high quality electron beam. To do that, the requirements of an optical electron source, such as current, radiation emission, etc. ...
Critical analysis of zeolite 4A synthesis through one-pot fusion hydrothermal treatment approach for class F fly ash Akın, Süleyman Şener; Kirdeciler, Salih Kaan; Kazanç Özerinç, Feyza; Akata Kurç, Burcu (2021-10-01) In this study, ‘‘One-pot fusion assisted hydrothermal synthesis’’ approach was employed to understand the nucleation and crystallization behaviour of the fusion product of Class F fly ash for zeolite 4A synthesis. Two sets...
Design, synthesis, molecular docking and ADME studies of novel indole-thiazolidinedione derivatives and their antineoplastic activity as CDK6 inhibitors Kışla, Mehmet Murat; Zengin Karadayı, Fikriye; Baran, Sercan; Doğan, Tuğba; Mutlu, Pelin; Ateş-Alagöz, Zeynep (2021-09-01) Several 5-((5-substituted-1H-indole-3-yl)methylene)-3-(2-oxo-2-(3/4-substituted-phenylethyl)-thiazolidine-2,4-dione derivatives (9–24) were designed and synthesized as CDK6 inhibitors, and their anticancer activity w...
Enhancing esophageal repair with bioactive bilayer mesh containing FGF Cesur, Ozkan; Endoğan Tanır, Tuğba; Celepli, Pinar; Ozarslan, Fatma; Hucumenoglu, Sema; KARAİBRAHİMOĞLU, Adnan; Hasırcı, Nesrin (2021-09-01) We aimed to prepare a bioactive and biodegradable bilayer mesh formed by fibroblast growth factor (FGF) loaded gelatin film layer, and poly epsilon-caprolactone (PCL) film layer, and to investigate its treatment efficacy o...
Design, synthesis, molecular docking and ADME studies of novel indole-thiazolidinedione derivatives and their antineoplastic activity as CDK6 inhibitors Kışla, Mehmet Murat; Zengin Karadayı, Fikriye; Baran, Sercan; Doğan, Tuğba; Mutlu, Pelin; Ateş-Alagöz, Zeynep (2021-09-01) Several 5-((5-substituted-1H-indole-3-yl)methylene)-3-(2-oxo-2-(3/4-substituted-phenylethyl)-thiazolidine-2,4-dione derivatives (9–24) were designed and synthesized as CDK6 inhibitors, and their anticancer activity w...
Microporous vanadosilicate films with tailorable V4+/V5+ ratio to achieve enhanced visible-light photocatalysis Kuzyaka, Duygu; Uzun, Ceren; Yıldız, İlker; Kaya, Murat; Akata Kurç, Burcu (2021-08-01) This study investigates the changes induced into the photocatalytic activity under solar light irradiation upon changing the structural film properties and tailor the concentration of defects in microporous vanadosilicate ...
Yhthesis, Antineoplastic Activity And Molecular Docking Studies Of Novel Indole- Thiazolidinedione Derivatives Kışla, Mehmet Murat; Zengin Karadayı, Fikriye; Doğan, Tuğba; Mutlu, Pelin; Alagöz, Zeynep (2021-06-22) Introduction: Cyclin-dependent kinase 6 (CDK6) became a valid target for breast cancer therapy over the past decades. Binding of this enzyme to E2F transcription factors eventually controls cell div...
The Site Preferences of Transition Elements and Their Synergistic Effects on the Bonding Strengthening and Structural Stability of gamma '-Ni3Al Precipitates in Ni-Based Superalloys: A First-Principles Investigation Eriş, Rasim; Akdeniz, Mahmut Vedat; Mehrabov, Amdulla (2021-04-01) Advanced mechanical properties of Ni-based superalloys strongly depend on the site preferences of alloying X elements in gamma '-Ni3Al-X precipitates, which are associated with the partial bonding characteristics between N...
Evaluation of methylation profiles of an epidermal growth factor receptor gene in a head and neck squamous cell carcinoma patient group Mutlu, M.; Mutlu, Pelin; Azarkan, S.; Baylr, Ö.; Öcal, B.; Saylam, G.; KORKMAZ, MEHMET HAKAN (2021-03-23) Upregulation of the epidermal growth factor receptor (EGFR) gene has shown an important impact on the development of head and neck cancers due to its important regulation role on multiple cell signaling pathways. The aim o...
Improvement of electrical characteristics of SnSe/Si heterostructure by integration of Si nanowires Coskun, E.; Güllü, Hasan Hüseyin; Emir, C.; Parlak, M. (2021-03-01) In this study, the effects of the nanowire geometry on Si wafer substrate were investigated for the SnSe/Si-nanowire heterojunction device and the obtained results were compared with the one fabricated on planar Si surface...

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